Deoxyuridine monophosphate (dUMP), also known as deoxyuridylic acid or deoxyuridylate in its
conjugate acid and conjugate base forms, respectively, is a
deoxynucleotide
A deoxyribonucleotide is a nucleotide that contains deoxyribose. They are the monomeric units of the informational biopolymer, deoxyribonucleic acid (DNA). Each deoxyribonucleotide comprises three parts: a deoxyribose sugar (monosaccharide), a nitr ...
.
It is an intermediate in the metabolism of
deoxyribonucleotides.
Biosynthesis
Deoxyuridine monophosphate (dUMP) is the deoxygenated form of
uridine monophosphate (UMP), and is the precursor to deoxythymidine monophosphate (dTMP), a component of DNA
nucleotide biosynthesis. By replacing the
hydroxyl group
In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula and composed of one oxygen atom covalently bonded to one hydrogen atom. In organic chemistry, alcohols and carboxylic acids contain one or more hydroxy g ...
at the 2' carbon of ribose with a hydrogen, UMP becomes deoxygenated to dUMP.
The synthesis of deoxyuridine monophosphate (dUMP) is a multi-step process that begins with
uridine monophosphate (UMP), the product of
pyrimidine
Pyrimidine (; ) is an aromatic, heterocyclic, organic compound similar to pyridine (). One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has nitrogen atoms at positions 1 and 3 in the ring. The other ...
biosynthesis.
The enzyme
nucleoside monophosphate kinase converts UMP and
ATP
ATP may refer to:
Companies and organizations
* Association of Tennis Professionals, men's professional tennis governing body
* American Technical Publishers, employee-owned publishing company
* ', a Danish pension
* Armenia Tree Project, non ...
to
uridine diphosphate (UDP) and
ADP
Adp or ADP may refer to:
Aviation
* Aéroports de Paris, airport authority for the Parisian region in France
* Aeropuertos del Perú, airport operator for airports in northern Peru
* SLAF Anuradhapura, an airport in Sri Lanka
* Ampara Air ...
.
In the presence of excess ATP, the enzyme
ribonucleotide reductase
Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase (rNDP), is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. It catalyzes this formation by removing the 2'-hydroxyl group of th ...
initiates a chain reaction with UDP, which catalyzes the formation of deoxyuridine diphosphate (dUDP), which is then converted to deoxyuridine triphosphate (dUTP), then deoxyuridine monophosphate (dUMP) via the addition or removal of phosphate groups.
Interactive pathway map
See also
*
DCMP deaminase
*
Uridine monophosphate
Notes
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Nucleotides